On the (mis)use of deception in web-based research: Challenges and recommendations

The deception of research participants remains a controversial issue in the behavioral sciences. Current ethics codes consistently limit the use of deception to cases in which non-deceptive alternatives are unfeasible and, crucially, require that participants subjected to deception be debriefed correspondingly along with an option to withdraw their data after learning about the deception. These conditions pose a particular challenge in the context of web-based research because participants can typically discontinue a study unilaterally (i.e., dropout by simply closing the browser window) in which case full debriefing and an option to withdraw one’s data are no longer available. As a consequence, the study would no longer be compatible with ethical standards. Based on recent meta-analytical data, we provide an existence proof of this problem, showing that deception is used in web-based research with little to no indication of safeguards ensuring full debriefing and subsequent data withdrawal options. We close by revisiting recommendations for the (non-)use of deception in web-based research and offer solutions to implement such safeguards in case deception is truly unavoidable

Interactions of arbuscular mycorrhizal fungi, critical loads of nitrogen deposition, and shifts from native to invasive species in a southern California shrubland

Anthropogenic nitrogen (N) deposition and invasive species are causing declines in global biodiversity, and both factors impact the diversity and functioning of arbuscular mycorrhizal (AM) fungi. Shifts in arbuscular mycorrhizal fungal (AMF) communities can generate feedback to native plants and affect their success, as was observed in California’s coastal sage scrub, which is a Mediterranean-type shrubland threatened by invasive grasses. As vegetation-type conversion from native shrubland to exotic annual grassland increased along a gradient of increasing N deposition, the richness of native plant species and of spore morphotypes decreased. Rapid declines in all plant and fungal values occurred at the critical load (CL) of 10–11 kg N·ha−1·year−1, indicating that AM fungi respond to the same environmental signals as the plants, and can be used to assess CL. Shrub root colonization also decreased along the N gradient, but colonization of the invasive grass was dominated by a fine AMF endophyte that was unresponsive to elevated N. A greenhouse experiment to assess AMF functioning showed that the native shrub Artemisia californica Less. had a negative growth response to an inoculum from high-N but not low-N soils, whereas the invasive grass Bromus rubens L. had a positive response to both inocula. Differential functioning of AM fungi under N deposition may in part explain vegetation-type conversion and the decline of this native shrubland

Economic games: An introduction and guide for research

Prosocial behaviors constitute vital ingredients for all types of social interactions and relationships as well as for society at large. Corresponding to this significance, the study of prosocial behaviors has received considerable attention across scientific disciplines. A striking feature of this research is that most disciplines rely on economic games to measure actual prosocial behavior in controlled experimental settings. However, empirical research often fails to fully exploit the richness of this class of paradigms. The current work aims to overcome this issue by providing a theory-driven overview of and introduction to the variety of economic games for researchers in psychology and beyond. Specifically, we introduce prominent theories of games (Game Theory and Interdependence Theory) and show how the concepts from these theories can be integrated in a unifying theoretical framework considering games as providing specific situational affordances for behavior. Additionally, we describe several games in detail, including their structural features, the affordances they involve, the social motives that may guide behavior, the flexibility they entail to manipulate specific situational aspects and, thus, affordances, and typical research findings. We conclude that tailored selection and combination of games and game variants allows to obtain a unique understanding of the underlying psychological processes involved in prosocial behavior. As a practical tool for researchers, we also provide standardized game instructions and guidelines for the implementation of games in future research. Ultimately, the review can foster optimal use of economic games in future work and thereby set the stage for high-class, replicable, and innovative research on human prosociality

Bending our ethics code: Avoidable deception and its justification in psychological research

Deception of research participants has long been and remains a hot-button issue in the behavioral sciences. At the same time, the field of psychology is fortunate to have an ethics code to rely on in determining whether and how to use and report on deception of participants. Despite ongoing normative controversies, the smallest common denominator among psychologists is that deception ought to be a last resort – to be used only when there is no other defensible way to study a question or phenomenon. Going beyond previous normative discussions or inquiries into the mere prevalence of deception, we ask the fundamental question whether common practice is compatible with this interpretation of our field’s ethical standards. Findings from an empirical literature review – focusing on the feasibility of nondeceptive alternative procedures and the presence of explicit justifications for the use of deception – demonstrate that there is a notable gap between the last resort interpretation of our ethical standards and common practice in psychological research. The findings are discussed with the aim of identifying viable ways in which researchers, journal editors, and the scientific associations crafting our ethics codes may narrow this gap

The dark core of personality and socially aversive psychopathology

Objective: Although dark traits as studied in mainstream personality research and socially aversive psychopathology as studied in abnormal psychology intend to account for the same classes of behavior, their degree of conceptual and, consequently, empirical correspondence has remained limited at best. We aim to overcome this divide by demonstrating clear convergence between the common core of all dark traits (the Dark Factor of Personality, D) and the four prominent instances of socially aversive psychopathology: narcissistic, antisocial, paranoid, and borderline tendencies. Method: In a large-scale, eight-month longitudinal study we assessed D, basic personality (the six HEXACO dimensions), and narcissistic, antisocial, paranoid, and borderline tendencies at time 1 (N = 2,329) and the latter aversive tendencies again at time 2 (N = 668) using different inventories. Results: D predicted all instances of socially aversive psychopathology cross-sectionally and longitudinally, with a large effect size on average, beyond the six HEXACO dimensions and even beyond the very same instances (measured through a different inventory). Conclusions: Bridging mainstream personality and abnormal psychology, the findings reveal strong, theory-consistent correspondence between dark traits and socially aversive psychopathology once dark traits are viewed through the lens of their common core, D

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer - the CONKO 004 pilot trial

BACKGROUND: Advanced pancreatic cancer (APC), beside its high mortality, causes the highest rates of venous thromboembolic events (VTE). Enoxaparin, a low molecular weight heparin (LMWH), is effective in prevention and treatment of VTE. Some small studies indicated that this benefit might extend to patients with cancer and probably prolong survival due to independent mechanisms. We initiated this safety investigation to get feasibility information on intensified chemotherapy combined with LMWH in outpatients with APC treated in 1st line. METHODS: The trial was a prospective, open-label, single center investigation in outpatients with inoperable pancreatic cancer who were treated with intensified first-line chemotherapy along with concomitant application of subcutaneous LMWH. The combined chemotherapy consisted of gemcitabine 1 g/m2 (30 min), 5-FU 750 mg/m2 (24 h), folinic acid 200 mg/m2 (30 min), and Cisplatin 30 mg/m2 (90 min) on day 1 and 8; q3w for the first 12 weeks (GFFC) followed by gemcitabine alone in patients without cancer progression. The simultaneous application of prophylactic enoxaparin started on day 1 of chemotherapy with a fixed dose of 40 mg daily. Statistical analyses were performed using R 3.01 with software package CMPRSK and SPSS software v19.0. RESULTS: The investigation was stopped after recruitment of 19 patients. At this time 15 patients had completed the required 12 weeks of treatment. Based on 71 cycles of GFFC + enoxaparin (median 4/pt [range: 2-4]) and 108 cycles of single-agent gemcitabine + enoxaparin (median 4/pt [range: 0-18]) the cumulative frequency of NCI-CTC toxicities grade 3/4 was below 10%. One case (5%) of a symptomatic non-lethal thromboembolic event was observed while receiving LMWH treatment. No severe bleeding event as defined in the protocol has been observed. The median overall survival was 10.05 [95%CI: 8.67-18.14] months. CONCLUSIONS: The addition of enoxaparin to GFFC chemotherapy is feasible, safe and does not appear to affect the efficacy or the toxicity profile of the chemotherapy regimen in patients with advanced pancreatic adenocarcinoma. Based on these findings we have initiated the randomized CONKO-004 trial to examine whether enoxaparin reduces the incidence of thromboembolic events or increases overall outcome. Trial registration: Clinical Trials NCT01945879

Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy

BACKGROUND: Advanced pancreatic cancer, in addition to its high mortality, is characterized by one of the highest rates of venous thromboembolic events (VTE) as compared to other types of cancer. Enoxaparin, a low molecular weight heparin (LMWH), has proven to be effective for the prevention and treatment of VTE in surgical and general medical patients. Results of some small studies suggest that this benefit might extend to patients with cancer, however, enoxaparin is not currently indicated for this use. This phase IIb study was designed to analyze the efficacy of enoxaparin in patients with locally advanced or metastatic pancreatic cancer undergoing systemic chemotherapy. METHODS: The aim of this prospective multicenter trial is to compare concomitant treatment with enoxaparin to no anticoagulation in 540 patients. Primary endpoint is the incidence of clinically relevant VTE (symptomatic deep venous thrombosis (DVT) of the leg and / or pelvic and / or pulmonary embolism (PE)) within the first 3 months. Secondary endpoints include the incidence of symptomatic and asymptomatic VTE after 6, 9 and 12 months as well as remission at 3, 6, 9 and 12 months, overall survival and bleeding. Trial registration: isrctn.org identifier CCT-NAPN-16752, controlled-trials.com identifier: ISRCTN02140505. RESULTS: An interim analysis for safety performed after inclusion of 152 patients revealed no increased risk of bleeding (5 pts vs. 6 pts, Chi2: 0.763). CONCLUSIONS: PROSPECT is a pivotal study in elucidating the role of low molecular weight heparins in advanced pancreatic cancer. Its results will lead to a new understanding of the role of heparins in the prevention of venous thromboembolism and of their effect on survival, remission rates and toxicity of chemotherapeutic regimens

Superior olivary complex organization and cytoarchitecture may be correlated with function and catarrhine primate phylogeny

In the mammalian auditory system, the medial nucleus of the trapezoid body and the lateral superior olive (MNTB-LSO system) contribute to binaural intensity processing and lateralization. Localization precision varies with the sound frequencies. As recency of common ancestry with human beings increases, primates have improved low-frequency sensitivity and reduced sensitivity to higher frequencies. The medial part of the MNTB is devoted to higher frequency processing. Thus, its high-frequency-dependent function is nearly lost in humans and its role in binaural processing as part of the contralateral pathway to the LSO remains questionable. Here, Nissl-stained sections of the superior olivary complex of man (Homo sapiens), bonobo (Pan paniscus), chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), orangutan (Pongo pygmaeus), gibbon (Hylobates lar), and macaque (Macaca fascicularis) were compared to reveal differences and coincidences. From chimpanzees to humans, the size of the LSO decreased, and the MNTB as a compact nucleus nearly disappears. From chimpanzees to humans, the LSO/MNTB ratio increases dramatically too, whereas the LSO/MSO ratio remains 1.1; a finding that probably corresponds to the phylogenetic proximity between the species